False-positive immunoassay results for urine benzodiazepine in patients receiving oxaprozin (Daypro).
نویسندگان
چکیده
False-PositIve Immunoassay Results for Urine Benzodiazeplne In Patients ReceivIng Oxaprozin (Daypro’”), Paul D. Camara,’ Linda Audette,1 Kim Velletri,’ Paul Breitenbecher,2 Mark Rosner,’ and William C. Griffiths1’3 (‘Roger William Hosp., Dept. of Pathol. and Lab. Med., and Brown Univ. Program in Med., 825 Chalkstone Ave., Providence, RI 02908; 2Sturdy Memorial Hosp., Dept. of Pathol. and Lab. Med., 211 Park, Attleboro, MA 02703; author for correspondence: fax 401-456-2138)
منابع مشابه
Oxaprozin interference with urinary benzodiazepine immunoassays and noninterference with receptor assay.
Immunoassay methods are widely used to screen for urinary benzodiazepines despite several reports of false-positive and false-negative results (1). False-negative results are produced for certain benzodiazepines that have no or low cross-reactivity with the immunoassay used. False-positive results were produced by four commercial immunoassays (Behring EMIT d.a.u., Behring EMIT II, Abbott FPIA, ...
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Cross-reactivities of some over-the-counter and uncontrolled prescription drugs with the immunoassays of some classes of drugs of abuse have been reported (1–17). Chemical structure similarity is a cause for cross-reactivity in immunoassays because the cross-reacting compound can fit onto the active sites in the antibody that has been developed for the drug of abuse or its chemical class. Howev...
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A method for the extraction of oxaprozin from equine urine and serum and its quantitation by high-performance liquid chromatography-ultraviolet detection is presented. Confirmation of oxaprozin in postadministration extracts was accomplished by gas chromatographic- mass spectrometric analysis of methylated extracts or liquid chromatography with tandem mass spectrometry daughter ion mass spectra...
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BACKGROUND Eradicating or appreciably limiting controlled prescription drug abuse, such as opioids and benzodiazepines, continues to be a challenge for clinicians, while providing needed, proper treatment. Detection of misuse and abuse is facilitated with urine drug testing (UDT). However, there are those who dispute UDT's diagnostic accuracy when done in the office (immunoassay) and claim that...
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Screening tests (UDSTs) for the diagnosis of psychoactive drugs can identify drug abuse, improve workplace safety, ensure community health, and play a critical role in therapeutic drug monitoring. Nonetheless, correct interpretation of the results of these tests requires a full awareness of the principles of testing methods, drug kinetics, and various leading causes of false results. Among the ...
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 41 1 شماره
صفحات -
تاریخ انتشار 1995